Vardenafil and Cardiovascular Risk

Vardenafil and Cardiovascular Risk

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Vardenafil is a PDE5 inhibitor used for treatment of erectile dysfunction. It is a tablet that is taken orally and works in the body within minutes. It is absorbed rapidly in the gastrointestinal tract and has a high absolute bioavailability of about 15%. It is extensively metabolized by the enzyme CYP3A4 to several pharmacologically active metabolites, the most important of which is N-desethyl vardenafil (M1) and has an elimination half-life of about 4-5 hours.

This drug is only for use in males. It is not safe for women, especially those who could become pregnant or are breast-feeding. It should not be used in combination with nitrates, such as those found in heart medicines, and should not be used by people who have severe liver or kidney disease. People with these conditions should only take vardenafil under the care of their doctor. It is also important to tell your doctor about any other medications or herbal supplements you are taking, including st. john’s wort.

A new long-term study suggests that vardenafil can help reduce cardiovascular risk in type 2 diabetes patients with mild to moderate erectile dysfunction. The research is published in the journal Circulation. The study is based on a large clinical trial of patients with type 2 diabetes mellitus and erectile dysfunction (ED).

In the randomized controlled trial, men were divided into groups to receive either vardenafil or placebo. They were monitored for 24 weeks for changes in glycemic control, blood pressure and flow-mediated dilation (FMD) measures and for the development of ED. The researchers also looked at whether vardenafil was associated with a reduced risk of a heart attack or stroke.

The vardenafil group had a lower rate of death, heart attack or stroke compared to the placebo group, although this Link difference was not statistically significant. The results also showed that vardenafil was associated with an increased rate of a reduction in systolic blood pressure and a significant increase in FMD dilation, both of which can lead to improved vascular function.

While vardenafil may be effective in treating some forms of ED, it is not an effective treatment for ED caused by psychological factors, such as stress or anxiety. In those cases, psychotherapy is recommended.

Vardenafil can be taken with or without food and should be taken at least 60 minutes before sexual activity. It is not an aphrodisiac and does not affect the libido, but it can cause an erection that lasts for up to four hours. It should not be used more than once per day, and it should not be taken with nitrates such as those in nitroglycerin (Nitrostadyl, Nitro-Bid, Isordil) or guanylate cyclase stimulators such as adenosine monophosphate (AMP) citrates (including Lidocaine, Deponit). You should avoid drinking grapefruit juice while taking this medication. You should also inform your doctor if you have ever had an erection lasting longer than 4 hours, or if you have any other medical problems.

 

 

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